All About Andarine S4: Benefits, Side Effects and How to Use It


When it comes to Selective Androgen Receptor Modulators (SARMs), one thing is on everyone’s mind: which SARM is the best one?

Well, we cannot give you a clear answer to this question. After all, some SARMs are especially great for bulking, for example, while others are famous for their fat loss effects.

Still, in this article, we’ll tackle the subject of one of the most famous compounds out there — Andarine. Here, you will find all the information you need to make a well-informed choice when choosing your next supplement.

About Andarine (S4)

Among the many research chemicals currently on the market, we’d say that it is one of the most widely used ones. However, its history shows that it wasn’t actually created for exercise enthusiasts around the globe. In fact, when GTX inc first developed it, the primary purpose was to offer treatment for diseases such as osteoporosis and muscle wasting. However, its development was later on halted.

Still, Phase I human trials showed that it could grace us with many other benefits as well. Andarine S4 is well known for its anti muscle wasting trait. Furthermore, the selective androgen receptor modulator can help people get stronger, leaner, and fitter in a matter of weeks.

Of course, most SARMs are frowned upon in professional bodybuilding communities. We cannot help but appreciate all the features they have and how they can help us achieve the body of our dreams. Thus, Andarine is still used by many who want to build up their endurance and physical stamina, increase strength, protect their bones by increasing bone mineral density and avoid injuries commonly associated with vigorous workout routines. Moreover, since the side effects are minimal and nothing like what we can experience when taking steroids, this selective androgen receptor modulator is an excellent choice for anyone looking to up their game at the gym.

How does it work?

When it comes to SARMs, one needs to understand that everyone has androgen receptors in their bodies. These androgen receptors are the one that actually makes or breaks our workout routine since they target the prostate gland. When influenced by certain chemicals, the SARM can help us work out longer than usual.

However, it can interact with three types of chemicals: AR antagonists, agonists, and modulators. Andarine is an AR modulator, which works differently from the antagonists and agonists. Instead of blocking the receptor (antagonist) or bonding, detaching, and reattaching to it (agonist), a modulator actually changes the structure of the AR.

Those changes can come in various forms. Still, they usually change the potency of testosterone and other AR chemicals by boosting testosterone levels.

Another effect is that Andarine will not cause dihydrotestosterone (DHT) or estrogen issues.


Benefits of using it

Now, we know that everyone has been waiting for this part — the benefits of using Andarine.

There are quite a few of these, and usually, no side effects follow them. However, we will talk about some of the minor consequences of taking Andarine S4 entails a bit later on.

First, let’s start with the fact that Andarine is great for weight loss (cutting cycles) and increasing bone density and bone tissue. Indeed, when used, Andarine S4 increases body fat oxidation but decreases lipoprotein lipase. Thus, Andarine can help us achieve that hard look we want our muscles to have since it decreases body fat. But we won’t feel bloated or horrible about ourselves since the SARM doesn’t increase water retention! Its effect on the bones also means that individuals struggling with osteoporosis can also benefit hugely here. In addition to that, the compound increases physical strength, and that’s why athletes use it to boost their performance in the gym.

Since this SARM has anabolic and androgenic effects, we won’t lose our muscle weight, which can often happen while cutting. Moreover, Andarine also has nutrient partitioning effects, and it’s especially effective if we want to recompose our bodies. However, we should note here that it’s not as strong as some steroids. So for best recomposition results, we ought to combine it with other products, like Cardarine and Ostarine. Looking at these results, it makes perfect sense that Andarine S4, and SARMs in general, are banned by the world anti-doping agency.

Any strange effects we need to know about?

One of the most important things about choosing a supplement is finding out whether it will have an undesirable effect on our sexual organs or our masculine/feminine features. Luckily, we don’t have to worry about that when it comes to Andarine S4.

The effect it has on the growth of our sexual organs is very minimal. Also, the SARM doesn’t affect the breast size in women, nor does it lead to gynecomastia. There haven’t been any reports about liver damage either, which is a common occurrence when using steroids.

This SARM won’t affect the way we look in terms of females growing a beard. In fact, if any women out there are considering using these products, Andarine S4 is a good choice, as it’s very female-friendly.

Finally, one of the best things about Andarine S4 is that it won’t enlarge our inner organs, such as our hearts, and it doesn’t lead to hepatitis and hepatotoxicity. This compound also burns body fat fast and you don’t need any post cycle therapy after finishing a cycle.

Side effects

We’ve already mentioned that there are certain minor side effects to using Andarine S4. In order to understand who can use this SARM and how we’ll try to explain what they are.

It’s important to note that, unlike steroids, these substances cannot actually lead to hair loss, acne, and other more serious consequences that anabolic injectables can produce. Their nature is not harmful, as they are quite selective about the effects they have on our bodies.

Still, Andarine S4 does have some side effects all users should be aware of. For example, out of all the Selective Androgen Receptor Modulators out there, the compound is best known as the one that can cause some night vision issues. The S-4 molecule found in it can actually bind to the retina in our eye. This may lead to users seeing a yellow tinge.

This yellow tint side effect, as we may call it, can lead to bad nighttime vision. However, users do say that smaller doses shouldn’t lead to this problem. Moreover, as soon as we finish taking Andrine, our vision goes back to normal.

While Andarine may not be the primary source of hair loss, data shows that it can actually expedite the process if you are genetically predisposed to go bald.

Another serious side effect you should know is testosterone suppression. This is a problem caused by different SARMs and not just Andarine. Fortunately, you can deal with the problem by running PCT (Post Cycle Therapy) at the end of each cycle.

Can we stack it? YES!

One of the best things about SARMs is that, although they are quite potent when used individually, they are especially effective when stacked.

For those who want to bulk up, a great idea is to stack Andarine S4, 50mg per day, with Testolone (RAD140) at 10mg per day.  Andarine has a short half-life so remember to split the dosage into two servings. While taking this combination, users should also adopt a diet that increases caloric intake. The results will be evident after eight to twelve weeks. Some athletes also stack Andarine with Ligandrol (LGD4033) at dosages of around 50mg and 10mg respectively to boost their strength levels.

Here is a crucial reminder for all users; always watch your dosages closely whenever you are stacking SARMs. These drugs are typically safe, but when they’re used together, they can become very dangerous even for seasoned weightlifters.


As with any other supplement out there, using something artificial to help us work out means that we need to take great care when it comes to dosage. Thus, men should take only 50 mg of Andarine S4 per day. Moreover, they should only use it for about eight to twelve weeks. Women, on the other hand, should take only 25 mg of Andarine per day. Bear in mind that the dose may vary slightly from one user to the next. You could also try to experiment with the dose range of 25mg to 50 mg per day to find your sweet spot.

What’s certain about both genders is that they should take Andarine S4 in two doses during the day. Andarine S4’s half-life is about four to six hours, so in order to get the best effect, one would need to take one dosage in the morning and another one later in the day.

Still, the best news of all is that Andarine S4 is not a stimulant. So if you love working out at night, you can safely take it before bedtime, as it won’t lead to insomnia.

Safe, effective, and proven to work, Andarine S4 is a potent choice

Though anabolics are still the preferred supplements for most bodybuilders and athletes, it’s essential to remind everyone about how unhealthy they are. Moreover, today, there’s no need to take these harmful substances when we can all just take Andarine S4 and protect, as well as maintain our physique the right way. Sure, it also comes with a good share of side effects but they are not even half as terrible as the ones from steroidal drugs. Andarine is a great product to prevent conditions like lean muscle wasting, gain bone strength and body weight and build up lean muscle mass by stimulating gene expression without any water retention. Prostatic hypertrophy (increasing prostate gland) is another side effect you’ll never have to worry about.

Andarine S4 is exactly the kind of SARM that will aid weight loss, gain lean muscle mass, increase bone density and bulk up or change our bodies completely. All we have to remember is that we need to take the right dosage so that we don’t experience any side effects. After all, staying healthy, even when using safe compounds like Selective Androgen Receptor Modulators, is of the essence!

Keep in mind that Andarine S4 is banned by the US anti-doping agency so don’t even think about it if you compete in professional sports!

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