Pyritinol Review: Benefits & Side Effects Reviewed


Vitamin B6 is one of the essential vitamins in the body and especially in the brain. This vitamin plays a critical role in the production of key neurotransmitters such as Dopamine, Epinephrine, Serotonin, and Glutamate. For this reason, the use of Vitamin B6 has always been linked to the enhancement of brain performance. Since the early 1990s, Vitamin B6 has been experimented on and not just as a nootropic but also for the treatment of dementia and in reversing the symptoms of cognitive decline that come with conditions such as Alzheimer’s disease.

Pyritinol is a unique supplement that is made of two Vitamin B6 molecules that are bound together with a disulfide bridge i.e., two sulfur atoms. The supplement is also known by the brand name Encephabol. You can also find it under the names Pyrithioxine, Ence, and Renervol. Other than reversing cognitive decline and boosting cognition, there have been reports showing that Pyritinol is also helpful for the treatment of hangovers and in improving reaction time.


What are The Benefits of Pyritinol?

  1. Improving Cognitive Function

Pyritinol is an old nootropic that is known to boost various brain functions. Ingestion of the drug increases the utilization of glucose, and it also boosts cGMP levels inside the brain. With lots of glucose in the brain, the vital organ will now have a surplus in energy, and this serves to increase functions such as concentration, decision making, and impulse control. It also helps in preventing brain fog.

Pyritinol also boosts reasoning, learning, and memory. This chemical crosses the blood-brain barrier to reach the central nervous system. Once there, it boosts the uptake of choline within the neurons, causing an increase in acetylcholine. It’s the increase of acetylcholine, which boosts cognitive functions, and it also supports cerebral health.

  1. Enhances Mood and Fights Anxiety

Dopamine is a crucial neurotransmitter that determines one’s mood. Low levels of dopamine have been linked to anxiety, depression, and other similar issues. On the other hand, an increase in dopamine helps in enhancing mood, fighting anxiety, and enhancing one’s ability to focus and concentrate.

Pyritinol is known to function as a precursor to dopamine, and it actually has excellent conversion. Its conversion into dopamine causes a significant increase in the levels of this neurotransmitter, and as a result, the feelings of pleasure increase.

This means that Pyritinol is not just helpful for boosting cognition, but it can actually be used as a mood enhancer. Individuals struggling with mood and anxiety disorders will find it very helpful.

  1. Reduces Hangover

Some studies have reported that consumption of Pyritinol reduces alcohol-induced hangovers. What Pyritinol does is it prevents the inflammation caused by methanol and formaldehyde thanks to its prostaglandin inhibitory properties.

Another trial available on the British Medical Journal reported that Pyritinol is also effective in reducing inflammation in the cerebrum. This helps in combatting the headache synonymous with hangovers. Users reported feeling almost instant relief after taking Pyritinol.

  1. Boosts Immune Response and Fights Autoimmune Inflammatory Disorders

Inflammation is the body’s way of fighting pathogens and infections. However, when there is too much or unnecessary inflammation i.e., chronic inflammation, this immune response becomes very dangerous. An example of an autoimmune disease that comes from such a problem is rheumatoid arthritis.

Researchers have reported that Pyritinol can trigger neutrophil functions and boost neutrophil cGMP levels. As a result, the drug helps to fight and reduce the symptoms associated with autoimmune inflammatory diseases such as Rheumatoid Arthritis.

Pyritinol also supports the movement as well as the sustainability of neutrophils. It helps the neutrophils move to areas where they are most needed. This is very crucial in maintaining an effective immune system considering that neutrophils are responsible for fighting infections in the body.

  1. Enhances Response to Stress

Pyritinol stimulates the activities of a section of the brain known as locus coeruleus. It is this part of the brain that regulates the production of norepinephrine and stress reactions. Therefore, by stimulating the area, Pyritinol causes an increase in norepinephrine levels. This consequently improves an individual’s reaction to stress. In addition to that, anxiety levels will go down, and the user will feel a boost in their overall well-being.

  1. Protects The Brain Against Free Radicals

Pyritinol has antioxidative properties. This is useful in protecting cells against the free radicals that are in the body. Pyritinol protects brain cells in specific. It helps to keep the neurons, proteins, and DNA safe from radicals.


Side Effects of Pyritinol

Cases of side effects linked to Pyritinol are very rare. This has been observed in research studies and also by the people who are already using this compound.

But this doesn’t mean that Pyritinol is completely safe. In certain instances, users may experience minor adverse reactions. These could be due to a person’s negative reaction to the drug due to sensitivity or allergies. It could also be as a result of taking the drug in high doses. In any case, the side effects are typically minor. You could also avoid them altogether by using the drug as directed.

With that in mind, some of the commonly reported side effects of Pyritinol are insomnia, decrease in appetite, nausea, rashes, irritability, and diarrhea.

You will notice that the side effects are similar to the ones associated with stimulants. That’s because Pyritinol is a CNS stimulant. The good news is that sticking to the right doses should keep you safe.

How to Use Pyritinol: Pyritinol Dosage

Pyritinol is an oral supplement that should be taken with a glass of water. You can take the pills with or without food. Either way should be fine.

As for the doses, experts recommend the use of between 300 to 600 mg per day split into two or three servings per day. The exact dose that you’ll end up using will depend on several factors:

  • Your body’s response to the drug – If you are reacting well to the drug, then you can use more of it.
  • Medical history – A person with a complicated history is better off sticking to lower doses. This reduces the risks of possible complications.
  • The condition being treated – The exact issue being addressed will influence the amount of Pyritinol to be consumed.

To get the doses right, it’s best to get in touch with a medical provider. You can then discuss your medical history with them, and they’ll be able to guide you on the right dosages.

First-time users should start with the lowest dose possible. You can even go below 300mg and do 200 or 100 mg per day. This is crucial in making sure that your body’s initial response to the drug is tolerable. After monitoring your reaction for some time, you can now start increasing the dose gradually. Don’t make a massive increment i.e., if you started with 200mg per day, make an increment of around 100mg. Don’t double or triple the dose at once.

Something else really important when using Pyritinol is how you cycle it. Continued use of Pyritinol can result in intolerance. This is where the user is no longer feeling the impact of the drug unless they increase the doses significantly. This is both wasteful and dangerous. To avoid that, you need to cycle Pyritinol. Some people use it continuously for about 2 weeks before they take a 1-week break.

Can You Stack Pyritinol?

Stacks are a common trend in the supplements industry. When done right, they help users get the most out of each drug while keeping the risks involved low. However, doing it inappropriately can make all the supplements involved useless. Worst case? It can result in severe adverse reactions.

For Pyritinol, experts report that indeed you can stack it with other supplements to increase potency and boost the results. For instance, Pyritinol can be stacked with Racetam family nootropics such as Pramiracetam. This enhances cognitive functions tremendously.

Pyritinol can also be stacked with other choline supplements to increase the uptake of choline, thereby boosting various functions of the brain.

It’s good practice to consult a physician before combining any two supplements.

Where Can You Buy Pyritinol?

You can find Pyritinol for sale on different online stores. The supplement is legal in most countries, so you can buy it over the counter without a doctor’s prescription.

It’s very important to use high-quality Pyritinol, so you want to pay attention to the supplier you buy your supplements from. Low-quality Pyritinol is not just ineffective, but it can be harmful too.

Final Thoughts

Pyritinol is a safe and effective nootropic with so much potential. Studies have proved its ability to enhance brain performance and also in delivering additional benefits such as improving the immune system and reducing the symptoms of anxiety, depression, and mood disorder. However, you must use the drug properly. Don’t go beyond the recommended dose and do not use it without a doctor’s green light if you have a preexisting medical condition.

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