Sulbutiamine Review: Pro’s & Con’s and Best Place To Buy


Living in modern times can be exceptionally stressful. What’s more, it often leaves individuals with multiple physical and mental health complications.

It is undeniable that chronic fatigue, depression, anxiety, and nerve disorders among other conditions are continually on the rise, impeding people’s ability to enjoy life as it was intended.

With this apparently frightening awareness, it helps to know that there are solutions to help thwart some of these symptoms, and improve the quality of one’s life substantially.

Sulbutiamine is a nootropic supplement that has been widely touted to improve cognitive function, while also providing some physical benefits. Overall, it is said to enhance the quality of one’s life tremendously.

Chances are you’ve come across numerous marketing jargon, which is why I will just cut to the chase. The following is a comprehensive guide elucidating everything you should know regarding Sulbutiamine.


What is Sulbutiamine?

This is a synthetic form of vitamin B12, also known as Thiamine. It is said to be an effective brain booster and energy enhancer. The supplement was invented in the 1960s by the Japanese. Since then, it has been widely used to aid individuals in combating significant energy deficiencies and issues of mental performance.

Initially, the Japanese were looking for a cure for Beriberi, a thiamine deficiency. However, thiamine itself could not cure the patients due to its lack of bioavailability. Consequently, the Japs adapted a more bioavailable variation of thiamine in Sulbutiamine, which cured their population of a life-threatening disorder.

What Is the Difference Between Sulbutiamine and Thiamine?

For starters, it is crucial to note that Sulbutiamine was formed by bending two molecules of Thiamine with a Sulphur group. Anyway, thiamine is a water-soluble vitamin that contributes to energy production in the body. However, when applied in the treatment of people with thiamine deficiency, it was ineffective due to its bio-unavailability.

Unlike Thiamine, which is water-soluble, Sulbutiamine is fat-soluble, allowing it to cross the blood-brain barrier with much ease. As a result, this new adaptation became more effective at combating thiamine deficiencies. For instance, the latter can be used to treat individuals with Wernicke-Korsakoff Syndrome (WKS) and beriberi.

Sulbutiamine is a nootropic and an antioxidant used in various parts of the world to combat fatigue. It also has other remarkable properties such as protecting the brain, alleviating muscle weakness, and boosting memory, among other things.

Lets’ take a more in-depth look at the benefits of this remarkable molecule.

What are the Benefits of Sulbutiamine?

  • Improves Mood

Anecdotal reports include that many people have had their mood uplifted and that this supplement has had a positive effect on their motivation too. Numerous reports of reduced anxiety levels and a feeling of wellbeing were recorded after supplementation with this thiamine molecule.

Moreover, this supplement also upregulates the transition of dopamine, which, as we may know, is associated with feelings of pleasure and reward. As a result, supplementing with this substance has demonstrated a considerable improvement in mood.

  • Reduces Fatigue and Boosts Energy Levels

Thiamine is celebrated for its capacity to help the brain and overall body produce higher levels of energy. Given that this supplement is more bioavailable than its parent, thiamine, it readily crosses the blood-brain barrier, and it allows thiamine to be utilized more effectively.

Up to date, this supplement has been used to treat a wide range of fatigue-related conditions, including post-infection fatigue, multiple sclerosis-related fatigues, and even fatigue that happens for unexplained reasons.

Experts also submit that the fatigue-fighting capacity is linked to its ability to promote the production of glutamate, which is deemed the most significant excitatory neurotransmitter.

  • Improves Memory

Animal studies investigating the effectiveness of this supplement on memory demonstrated the formation of long-term memory. In humans, when the supplement was taken together with Donepezil, a medication used in the treatment of Alzheimer’s patients, it improved memory as well.

Poor memory is linked to low levels of choline activity in the brain. Sulbutiamine can potentiate cholinergic transmissions in the hippocampus and the prefrontal cortex of the brain. Increasing the available choline triggers the production of acetylcholine, which is substantially associated with cognition and memory.

  • Boosts Athletic Performance

A lot of neurohackers use this supplement for a boost in physical energy. This is so much the case that supplementing with Sulbutiamine has caused controversy in professional sports, especially after the Moscow Anti-Doping Center found traces of this supplement in 16000 blood samples while looking for traces of anabolic supplements in athletes.

Save for its ergogenic and stimulating properties, this supplement can also enhance focus and motivation, while also lowering fatigue among its recipients. All these factors combined, Sulbutiamine makes for an excellent supplement for athletes.

  • Treats Erectile Dysfunction

A significant number of men in today’s setting are confronted with psychogenic erectile dysfunction. For this particular condition, the inability to achieve and maintain an erection is usually attributed to psychological factors (hindered brain activity and mental stress).

What does this mean? If one can alleviate mental stress and simultaneously stimulate brain activity, one can create a more relaxed and improved mental state that directly impacts the body’s ability to develop and sustain strong erections.

To prove this hypothesis, a study was conducted on 20 men experiencing ED. They were all given Sulbutiamine for 30 days, after which 16 of them demonstrated a significant improvement.

Moreover, Sulbutiamine has demonstrated a 50% chance of correcting erectile dysfunction in men with arterial disorders in the penis.

  • Protects Nerves

Thiamine is known for its ability to support a healthy nervous system. Therefore, it is not surprising that science has been able to prove the potential of this supplement to remedy nerve damage caused by diabetes, which is a significant cause of nerve damage.

In six-week research, 15 participants were given daily doses of Sulbutiamine to test its effectiveness on nerve function. At the end of the study, the study group demonstrated a significant improvement in nerve and muscle function, unlike the placebo.

Sulbutiamine Dosage

The recommended dosage is 400 mg to 1000 mg per day. Higher doses should be split into two servings.

Anecdotal reports warn about dosing too late in the day as its mild stimulant effects could interfere with sleep.

Again, if you are using this supplement for the first time, it is advisable that you start with a reasonable dose to gauge your tolerance levels.

Building tolerance for this supplement may affect its effectiveness. As such, it is recommended that you cycle the product when using it for prolonged periods. For instance, you can take the supplement for five days and resume your dosage two days later.

If you want to stack this supplement, you can try a renowned stack that also incorporates choline and Huperzine-A. This stack will provide you with an extra memory boost and increased focus.

The recommended dosage for the stack is 200 mg Sulbutiamine+200 mcg Huperzine +300 mg Choline (Alpha GPC).

Is Sulbutiamine Safe?

Yes. This supplement can be termed as relatively safe, given that it is well-tolerated and not toxic.

Although side effects are rare, they may occur and are distinct from various individuals.

Some of the undesirable effects include:

  • Skin rashes and eczema-like outbreaks at extremely high doses
  • Mood swings, particularly if one has bipolar or is under medication for the same
  • Insomnia, especially when taken during the late hours of the day
  • Nausea
  • Headaches

There are some reports about this supplement causing addictive tendencies. This is reasonable as it affects the levels of dopamine in the brain.

In case you experience any of the following side effects, it is advisable that you stop using the supplement immediately. What’s more, you should always consult with your physician before taking any over the counter supplement.

Tips for Purchasing Sulbutiamine

Foremost, this supplement is legal, both in Canada and the United States. As a result, finding it is relatively easy. Many people prefer online shopping due to the convenience, although brick and mortar stores will still have the product.

You can rest assured that this supplement is in stock at Amazon and other online outlets such as Vitacost.

Purchasing this product in bulk will make it more affordable, especially if you are also buying other supplements consistently each month.

This supplement is available in both powder and capsule form. Tablets and capsules usually contain 750 mg in each pill.


You have to admire the existence of such a potent supplement that has been tested and proven over decades of research and practical use. Sulbutiamine is known to treat various forms of fatigue, and both anecdotal reports and scientific studies confirm that it can enhance memory, cognition, mood, and motivation.

What’s more, this supplement can give you a substantial increase in mental clarity, and boost your energy both physically and mentally, leaving you awake and alert. At the same time, it is said to be well-tolerated and non-toxic, which makes it relatively safe to consume.

Overall, if you are among the millions who experience physical or mental fatigue, among other issues addressed in this text, this supplement may be what you were looking for.

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